Vitamin B6 is a water-soluble vitamin that is present in many natural and enriched foods. It can also be administered as a dietary supplement, if necessary. Vitamin B6 is a general name for six chemically similar compounds (vitamers) with vitamin B6 activity.

B6 has a variety of functions in our body, it takes part in over 100 enzyme reactions, and is involved in protein metabolism.

It`s deficiency in the body has been linked to dermatitis, scaling on the lips and cracks at the corners of the mouth, glossitis (swollen tongue), microcytic anemia, depression, confusion, and weakened immune system (1). How to know if you might suffer from B6 deficiency and what is the best treatment? In this profound article you`ll find the answers for all these questions.

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Vitamin B6 Role in Your Body

Vitamin B6 has several tasks:

  • One of the central roles of this vitamin is in protein metabolism where it helps regulate the balance of amino acids in the body.
  • Needed for hormone production.
  • Your body requires B6 for the formation of various bioactive compounds such as serotonin, erythrocytes, hemoglobin and lymphocytes.
  • Vitamin B6 plays a role in the metabolism of protein, carbohydrates and fats, the production of neurotransmitters and the formation of nicotinic acid.
  • It is vital for maintaining a healthy nervous system, skin, muscles and blood.
  • To a large extent, B6 levels depend on the central nervous system and hydrochloric acid productivity. It is therefore also necessary to absorb magnesium and vitamin B12.
  • B6 is necessary for the synthesis of several neurotransmitters, heme and for the metabolism of glycogen, fatty acids and steroids.
  • This vitamin is necessary for creating neurotransmitters that regulate emotions, including serotonin, dopamine and gamma-aminobutyric acid (GABA) (5).

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Vitamin B6 Benefits

B6 has been found to have some link between certain health conditions:

  • Mood and depression – May improve mood and reduce symptoms of depression.
  • Brain function and Alzheimer’s disease – B6 may prevent a decline in brain function by decreasing homocysteine levels that have been associated with Alzheimer’s disease and memory impairments. However, studies have not proven the effectiveness of B6 in improving brain health.
  • Anemia – May prevent and treat anemia by aiding hemoglobin production.
  • Anxiety – According to some research, high doses of B6 may decrease anxiety and other mood issues associated with PMS due to its role in creating neurotransmitters.
  • Nausea and vomiting –  Vitamin B6 supplements in doses of 30–75 mg a day have been used as an effective treatment for nausea and vomiting during pregnancy.
  • Clogged Arteries and Reduce Heart Disease – B6 may help reduce high homocysteine levels that lead to narrowing of arteries. This may minimize heart disease risk.
  • Cancer – Some observational studies suggest a link between adequate dietary intake and blood levels of B6 and a decreased risk of certain types of cancer, but more research is needed.
  • Eye DiseasesVitamin B6 supplements may reduce your risk of age-related macular degeneration (AMD). Additionally, adequate blood levels of B6 may prevent issues that affect the retina. However, more research needs to be done.
  • Rheumatoid Arthritis – Inflammation associated with rheumatoid arthritis may lower the vitamin B6 levels in blood. High doses of B6 may help correct deficiencies and reduce inflammation, but more research needs to be done to confirm these effects.
  • Premenstrual Syndrome – Some evidence suggests that vitamin B6 supplements could reduce the symptoms of premenstrual syndrome (PMS), but conclusions are limited due to the poor quality of most studies (1, 6).

However, do not start to self medicate and consult your doctor before taking any dietary supplements, as more research needs to be done to prove the effects of B6 in treating diseases and other health conditions listed above.

Vitamin B& recommended intake
Source: National Institutes of Health

Recommended Intake

The national recommended daily intake is 1.5-1.7 mg. Pregnant and elderly people may take up to 2mg. Children much less. Up to 1 year no more than 0.3mg, up to 3 years not more than 0.5mg and up to 13 years not more than 1mg (1).

Following national recommendations, these amounts should be sufficient for a healthy person to achieve the necessary level of vitamin B6 in the body. However, this vitamin also participates in the metabolism of proteins. Therefore, its significance and thus the necessity enlarges with the amount of protein consumed.

For example, athletes and people with severe physical activity may need more vitamin B6 because their muscles work more. So they use larger amounts of protein to maintain and build their muscles.

Consuming multiple times higher doses of regular and long-term daily doses may cause serious sensory disturbances such as ataxia. This essentially means losing control over your physical movements. The symptoms are proportional to the size of the overdose and usually disappear when the overdose stops. So be very careful with high doses and overconsumption.

Excessive intake of vitamin B6 may also cause dermatological problems, light curves, digestive problems, and nausea (1).

Groups at Risk of Vitamin B6 Inadequacy

Scientists have found that the current indicative quantities are not sufficient in many groups to prevent vitamin B6 deficiency.

The following groups are among those most likely to have inadequate intakes of vitamin B6:

  • Overweight people.
  • Elderly.
  • Pregnant women.
  • Individuals with impaired renal function.
  • Patients with celiac disease, Crohn’s disease, ulcerative colitis, and inflammatory bowel disease.
  • People with alcohol dependence.
  • Individuals with autoimmune disorders.
  • Certain genetic diseases, such as homocystinuria, can also cause vitamin B6 deficiency.
  • Some medications (antiepileptic drugs), can lead to deficiency over time (1).

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Vitamin B6 Deficiency

Vitamin B6 deficiency is not very common. If the level of B6 in the body is inadequate to carry out the vital tasks, then other vitamins from the B group are probably also lacking. Vitamin B6 deficiency may cause biochemical changes in your body which have clearly recognizable symptoms.

A severe and prolonged deficiency of this vitamin can cause:

  • Microcytic Anemia
  • Electroencephalographic abnormalities, electromagnetic disturbances in the brain
  • Mental health disorders
  • Cognitive impairment
  • Reduced immune response to pathological microorganisms
  • Dermatitis with cheilosis (scaling on the lips and cracks at the corners of the mouth) and glossitis (swollen tongue)
  • Depression and confusion
  • Weakened immune function (1, 4)

Mild deficiency of vitamin B6 can exist for years before some symptoms begin to occur. At this time, you may experience non-specific symptoms such as fatigue, irritability and loss of mood.

In children and especially infants, the deficiency primarily manifests in weight loss, irritability, abnormally acute hearing, and convulsive seizure. In more severe cases, in anemia and convulsions.

Certain diseases that prevent the kidneys from working can also contribute to the deficit. Also, B6 levels are low due to any diseases causing absorption problems such as Crohn’s disease, celiac disease and stomach ulcers. Some hereditary diseases such as homocystinuria (a metabolic disorder of amino acids), or medicines (for example prolonged use of contraceptive and antiepileptics) may also affect the absorption and overall levels of B6.

Homocysteine ​​Reference: > 13 a. 5 – 15 µmol / l. The higher the homocysteine level in blood, the greater the chance of B6 deficiency.

The level of homocysteine ​​in the blood increases with age. Also, it’s higher in men, smokers and people with low physical activity.

Vitamin B6 Sources
Source: National Institutes of Health

Vitamin B6 Sources

The human body absorbs vitamin B6 from both – plant and animal food. Intestinal microflora also produces B6. The best sources of this nutrition are fish, poultry, pork and beef from animal products. Also, animal liver and egg yolk. Vegetable sources are nuts, avocado, broccoli, paprika, potatoes, banana, bread, seeds and legumes.

If you feel that your diet is not varied and healthy enough, or you belong to a risk group, you should try high quality food supplements.

There are also separate B6 vitamins as food supplements, but they are usually taken with some other mineral or vitamin such as magnesium. In this case, it is most sensible to acquire a bioactive vitamin B complex that contains vitamins throughout the group spectrum where one supports the other.

In conclusion, the contents of this website is for informational purposes only and should not be substituted for the advice of your doctor or other qualified healthcare professional. Everybody is unique and results may vary, so please check with your doctor or other qualified health care professional before taking any nutritional supplements or starting any exercise program or other self-care practices.

Compiled by: Maria-Helena Loik

Pictures: Pixabay.com, Pexels.com, Shutterstock.com

Sources:

  1. https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/#:~:text=Vitamin%20B6%20deficiency%20is%20associated,function%20%5B1%2C2%5D.
  2. https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/
  3. https://www.sciencedirect.com/topics/chemistry/vitamin-b6
  4. https://www.healthline.com/nutrition/vitamin-b6-deficiency-symptoms
  5. https://www.sciencedirect.com/topics/chemistry/vitamin-b6#:~:text=One%20of%20the%20central%20roles,closely%20involved%20in%20hormone%20production.
  6. https://www.healthline.com/nutrition/vitamin-b6-benefits#:~:text=Vitamin%20B6%2C%20also%20known%20as,it%20from%20foods%20or%20supplements.

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